Altimetry for the future: Building on 25 years of progress

In 2018 we celebrated 25 years of development of radar altimetry, and the progress achieved by this methodology in the fields of global and coastal oceanography, hydrology, geodesy and cryospheric sciences. Many symbolic major events have celebrated these developments, e.g., in Venice, Italy, the 15th (2006) and 20th (2012) years of progress and more recently, in 2018, in Ponta Delgada, Portugal, 25 Years of Progress in Radar Altimetry. On this latter occasion it was decided to collect contributions of scientists, engineers and managers involved in the worldwide altimetry community to depict the state of altimetry and propose recommendations for the altimetry of the future. This paper summarizes contributions and recommendations that were collected and provides guidance for future mission design, research activities, and sustainable operational radar altimetry data exploitation. Recommendations provided are fundamental for optimizing further scientific and operational advances of oceanographic observations by altimetry, including requirements for spatial and temporal resolution of altimetric measurements, their accuracy and continuity. There are also new challenges and new openings mentioned in the paper that are particularly crucial for observations at higher latitudes, for coastal oceanography, for cryospheric studies and for hydrology. The paper starts with a general introduction followed by a section on Earth System Science including Ocean Dynamics, Sea Level, the Coastal Ocean, Hydrology, the Cryosphere and Polar Oceans and the ‘‘Green” Ocean, extending the frontier from biogeochemistry to marine ecology. Applications are described in a subsequent section, which covers Operational Oceanography, Weather, Hurricane Wave and Wind Forecasting, Climate projection. Instruments’ development and satellite missions’ evolutions are described in a fourth section. A fifth section covers the key observations that altimeters provide and their potential complements, from other Earth observation measurements to in situ data. Section 6 identifies the data and methods and provides some accuracy and resolution requirements for the wet tropospheric correction, the orbit and other geodetic requirements, the Mean Sea Surface, Geoid and Mean Dynamic Topography, Calibration and Validation, data accuracy, data access and handling (including the DUACS system). Section 7 brings a transversal view on scales, integration, artificial intelligence, and capacity building (education and training). Section 8 reviews the programmatic issues followed by a conclusion

Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study

Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods: This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings: This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (74·0%) had emergency surgery and 280 (24·8%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (26·1%) patients. 30-day mortality was 23·8% (268 of 1128). Pulmonary complications occurred in 577 (51·2%) of 1128 patients; 30-day mortality in these patients was 38·0% (219 of 577), accounting for 81·7% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 1·75 [95% CI 1·28–2·40], p\textless0·0001), age 70 years or older versus younger than 70 years (2·30 [1·65–3·22], p\textless0·0001), American Society of Anesthesiologists grades 3–5 versus grades 1–2 (2·35 [1·57–3·53], p\textless0·0001), malignant versus benign or obstetric diagnosis (1·55 [1·01–2·39], p=0·046), emergency versus elective surgery (1·67 [1·06–2·63], p=0·026), and major versus minor surgery (1·52 [1·01–2·31], p=0·047). Interpretation: Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding: National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. For example, a key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process versus those that measure fl ux through the autophagy pathway (i.e., the complete process including the amount and rate of cargo sequestered and degraded). In particular, a block in macroautophagy that results in autophagosome accumulation must be differentiated from stimuli that increase autophagic activity, defi ned as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (inmost higher eukaryotes and some protists such as Dictyostelium ) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the fi eld understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. It is worth emphasizing here that lysosomal digestion is a stage of autophagy and evaluating its competence is a crucial part of the evaluation of autophagic flux, or complete autophagy. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. Along these lines, because of the potential for pleiotropic effects due to blocking autophagy through genetic manipulation it is imperative to delete or knock down more than one autophagy-related gene. In addition, some individual Atg proteins, or groups of proteins, are involved in other cellular pathways so not all Atg proteins can be used as a specific marker for an autophagic process. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field

Altimetry for the future: building on 25 years of progress

In 2018 we celebrated 25 years of development of radar altimetry, and the progress achieved by this methodology in the fields of global and coastal oceanography, hydrology, geodesy and cryospheric sciences. Many symbolic major events have celebrated these developments, e.g., in Venice, Italy, the 15th (2006) and 20th (2012) years of progress and more recently, in 2018, in Ponta Delgada, Portugal, 25 Years of Progress in Radar Altimetry. On this latter occasion it was decided to collect contributions of scientists, engineers and managers involved in the worldwide altimetry community to depict the state of altimetry and propose recommendations for the altimetry of the future. This paper summarizes contributions and recommendations that were collected and provides guidance for future mission design, research activities, and sustainable operational radar altimetry data exploitation. Recommendations provided are fundamental for optimizing further scientific and operational advances of oceanographic observations by altimetry, including requirements for spatial and temporal resolution of altimetric measurements, their accuracy and continuity. There are also new challenges and new openings mentioned in the paper that are particularly crucial for observations at higher latitudes, for coastal oceanography, for cryospheric studies and for hydrology. The paper starts with a general introduction followed by a section on Earth System Science including Ocean Dynamics, Sea Level, the Coastal Ocean, Hydrology, the Cryosphere and Polar Oceans and the “Green” Ocean, extending the frontier from biogeochemistry to marine ecology. Applications are described in a subsequent section, which covers Operational Oceanography, Weather, Hurricane Wave and Wind Forecasting, Climate projection. Instruments’ development and satellite missions’ evolutions are described in a fourth section. A fifth section covers the key observations that altimeters provide and their potential complements, from other Earth observation measurements to in situ data. Section 6 identifies the data and methods and provides some accuracy and resolution requirements for the wet tropospheric correction, the orbit and other geodetic requirements, the Mean Sea Surface, Geoid and Mean Dynamic Topography, Calibration and Validation, data accuracy, data access and handling (including the DUACS system). Section 7 brings a transversal view on scales, integration, artificial intelligence, and capacity building (education and training). Section 8 reviews the programmatic issues followed by a conclusion

Global surveys of reservoirs and lakes from satellites and regional application to the Syrdarya river basin

International audienc

Multi-satellite approach and in-situ observations to study hydrology of boreal wetlands

International audienc

Multi-satellite approach and in-situ observations to study hydrology of boreal wetlands

International audienc

Anticipating the evolution of the Fitri lake system: temporalities of an overflowing flood and its socio-ecological consequences

International audienceThe Sahel, located at the southern edge of the Sahara is defined as the transitional boundary of the Sahara, whose aridification since the late Holocene has profoundly affected landscapes, human occupation and ecosystems. Current climate change, characterized by an increase in temperature, raised the idea of aridification and the disappearance of surface water in the Sahelian zone. However, in central Sahel, the trend towards increasing open water surfaces seems to be confirmed over the last decade, particularly during extreme rainfall episodes. Here, we show the current changes of Lake Fitri, a remnant of the mega-lake Chad during the Holocene 6,000 years ago, whose seasonal flooding has reached unequaled levels in the last 50 years. This terminal and shallow lake and spreading out over a vast flat sedimentary plain irrigates a variable surface area. During exceptional rainy years such as the current one (2020-2021), the waters from the Batha river basin (main tributary of Lake Fitri), in the Sahelian zone, can reach the Chari catchment area (main tributary of Lake Chad) by passing through a succession of basins.The diachronic analysis of Landsat images combined with ground-based observations recorded during the year 2020-2021 will be compared with the previous available time-series, in particular the monthly series already analysed for the year 2015 (Yalikun and al., 2019). The results confirm the trend towards the extension of the lake and the "outflow" of its waters to the west. These observations raise many questions related to the definition of a lake and its precise shoreline in this context. We will also specify the consequences in terms of the recomposition of the social-ecological system (changes in land use, recomposition of activity systems and access to natural resources, governance issues). Finally, we will discuss the timing of the changes observed in the short (annual, decade), medium (25 years), long and very long term (Holocene), on the comparability of these changes and on the elements to be considered in order to envisage the future evolution of such sahelian social-ecological system

Lake Chad hydrological cycle under current climate change

International audienceIn a near future, the Sahara and Sahelian regions could experience more rainfall than today as aresult of climate change. Wetter conditions in the hottest and driest place of the planet today raisethe question of whether the near future might hold in store environmental transformations,particularly in view of the growing human-induced climate, land-use and land-cover changes.Reflecting an enhancement of the global hydrological cycle under warmer conditions, someexperiments provide support for the notion of a strengthening of the monsoon in the future andmore rainfall in central Sahel and Sahara. However, some remote forcing could counterbalancethe decadal trend. Modeling experiments suggest that the freshwater discharge coming fromGreenland melting could significantly impact the sea surface temperature of North Atlantic andinduce a decrease in Sahel rainfall for the next decades, remaining left open the question howSahara will be in a warmer climate?By chance, Lake Chad, located at the southern edge of the Sahara, is recognized for being the bestsite in Africa for deciphering hydrological and climate change. After being ranked at the world’ssixth largest inland water body with an open water area of 25,000 km2 in the 1960s, it shrunkdramatically at the beginning of the 1970s and reached less than 2000 km2 during the 1980s,decreasing by more 90% in area. Because it provides food and water to 50 millions of people, itbecomes crucial to observe precisely its hydrological cycle during the last 20 years.Here by using a new multi-satellite approach combined with ground-based observations, we showthat Lake Chad extent has remained stable during the last two decades, slightly increasing at14,000 km2. We extend further this reconstruction by adding new data from the hydrological year2019-2020, which is considered at an extreme in precipitation recorded over the Sahel. Moreover,since the 2000s, groundwater which contributes to 70% of Lake Chad’s annual water storage, isincreasing due to water supply provide by its two main tributaries draining a catchment area610,000 km2 wide. Because the current climate change seems to be characterize by a higherinterannual variability affecting from year to year the amount of precipitation during the rainyseason and increasing the vulnerability of the economy of the region mainly based of agropastoralactivities, we investigate the yearly cycle and see how it is impacted the hydrological cycle of LakeChad and changed over time

Modelling hydrologic and hydrodynamic processes in basins with large semi-arid wetlands

International audienc